[CAS NO. 78950-78-4] 8-OH-DPAT (8-Hydroxy-DPAT)

Name: 8-OH-DPAT (8-Hydroxy-DPAT)
Brand: Arctom Scientific
SKU: SLK-S8447

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PRODUCTS SPECIFICATIONS [78950-78-4]

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Catalog

SLK-S8447

Brand

Selleck

CAS

78950-78-4

DESCRIPTION [78950-78-4]

Overview

MDL	-
Molecular Weight	247.38
Molecular Formula	C16H25NO
SMILES	OC1=C2C(CCC(N(CCC)CCC)C2)=CC=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.0424 mL	20.2118 mL	40.4236 mL
5 mM	0.8085 mL	4.0424 mL	8.0847 mL
10 mM	0.4042 mL	2.0212 mL	4.0424 mL
50 mM	0.0808 mL	0.4042 mL	0.8085 mL

Description

8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.

Targets

5-HT1A ^[1]
(Cell-free)

8.19(pIC50)

In vitro

The drug is only weakly effective at 5-HT1B subtype, the pIC50 being 5.42 ± 0.08 (n = 5). Since 8-OH-DPAT has no effect on 5-HT1B binding at concentrations lower than 100 nM. 8-OH-DPAT is able to reduce the accumulation of both autophagic-derived and photoreceptor outer segment-derived lipofuscin, increase antioxidant protection and reduce oxidative damage in cultured human RPE cells.

In vivo

Intravenous administration of the selective 5-HT1A-receptor agonist 8-OH-DPAT rapidly reverses the hypotensive and bradycardic responses established during severe hemorrhage with relatively little variability. 8-OH-DPAT is relatively lipophilic and readily crosses the blood-brain barrier.

References

[1] Middlemiss DN, et al. Eur J Pharmacol. 1983, 90(1):151-3.
[2] Montgomery AM, et al. J Neural Transm Gen Sect. 1991, 83(1-2):139-48.
[3] Scrogin KE. Am J Physiol Regul Integr Comp Physiol. 2003, 284(3):R782-91.
[4] Thampi P, et al. PLoS One. 2012, 7(4):e34468.

Synonyms

1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-

7-(Dipropylamino)-5,6,7,8-tetrahydro-1-naphthalenol

8-Hydroxy-2-(di-n-propylamino)tetralin

8-Hydroxy-N,N-dipropyl-2-aminotetralin

PAT

8-Hydroxy-2-(dipropylamino)tetralin

8-OH-DPAT

8-Hydroxy-DPAT

dl-8-Hydroxy-2-(dipropylamino)tetralin

(±)-8-Hydroxy-2-(di-n-propylamino)tetralin

(±)-7-(Dipropylamino)-5,6,7,8-tetrahydro-1-naphthalenol

(±)-8-Hydroxy-N,N-dipropyl-2-aminotetralin

(±)-8-OH-DPAT

(±)-8-Hydroxy-2-(dipropylamino)tetralin

(+)-8-Hydroxy-2-(di-n-propylamino)tetralin