[CAS NO. 150080-09-4] Talabostat (PT-100)

Name: Talabostat (PT-100)
Brand: Arctom Scientific
SKU: SLK-S8455

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PRODUCTS SPECIFICATIONS [150080-09-4]

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Catalog

SLK-S8455

Brand

Selleck

CAS

150080-09-4

DESCRIPTION [150080-09-4]

Overview

MDL	MFCD13194906
Molecular Weight	310.18
Molecular Formula	C10H23BN2O6S
SMILES	CS(=O)(O)=O.CC(C)[C@H](N)C(N1[C@H](B(O)O)CCC1)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.2239 mL	16.1197 mL	32.2393 mL
5 mM	0.6448 mL	3.2239 mL	6.4479 mL
10 mM	0.3224 mL	1.6120 mL	3.2239 mL
50 mM	0.0645 mL	0.3224 mL	0.6448 mL

Description

Talabostat (Val-boroPro, PT-100) is a inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.

Targets

DPP-4 ^[1] (Cell-free assay)	DPP-8 ^[1] (Cell-free assay)	DPP-9 ^[1] (Cell-free assay)	DPP-2 ^[1] (Cell-free assay)	PEP ^[1] (Cell-free assay)
<4 nM	4 nM	11 nM	310 nM	390 nM

In vitro

In vitro, talabostat upregulates cytokines/chemokines in human bone marrow stromal cells. Talabostat (Val-boroPro) induces monocytes and macrophage cell death. Val-boroPro induced pyroptosis requires caspase-1.

References

[1] Lankas GR, et al. Diabetes. 2005, 54(10):2988-94.
[2] Michael Jesson, et al. American Association for Cancer Research. 2007, 67(9):Supplement.
[3] Walsh MP, et al. PLoS One. 2013, 8(3):e58860.
[4] Marian C. Okondo, et al. Nat Chem Biol. 2017, 13(1): 46–53.