[CAS NO. 256476-36-5] UK-371804 HCl
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PRODUCTS SPECIFICATIONS [256476-36-5]
Store
Catalog
SLK-S8457
Brand
Selleck
CAS
256476-36-5
DESCRIPTION [256476-36-5]
Overview
| MDL | MFCD31558512 |
|---|---|
| Molecular Weight | 422.29 |
| Molecular Formula | C14H16ClN5O4S.HCl |
| SMILES | CC(C(O)=O)(C)NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O.[H]Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
UK-371804 is a potent and selective inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
Targets
| uPA [1] (Cell-free assay) |
| 10 nM(Ki) |
In vitro
In Vitro, UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM).
In vivo
In Vivo, in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters.
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