[CAS NO. 1105698-15-4] Salermide
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PRODUCTS SPECIFICATIONS [1105698-15-4]
Store
Catalog
SLK-S8460
Brand
Selleck
CAS
1105698-15-4
DESCRIPTION [1105698-15-4]
Overview
| MDL | MFCD12912446 |
|---|---|
| Molecular Weight | 394.47 |
| Molecular Formula | C26H22N2O2 |
| SMILES | CC(C1=CC=CC=C1)C(NC2=CC=CC(/N=C/C3=C4C=CC=CC4=CC=C3O)=C2)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5350 mL | 12.6752 mL | 25.3505 mL |
| 5 mM | 0.5070 mL | 2.5350 mL | 5.0701 mL |
| 10 mM | 0.2535 mL | 1.2675 mL | 2.5350 mL |
| 50 mM | 0.0507 mL | 0.2535 mL | 0.5070 mL |
Description
Salermide is a reverse amide with a strong in vitro inhibitory effect on and . Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
In vitro
Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent.
In vivo
Salermide is well tolerated by mice at concentrations up to 100 μM. Its feeding does not produce any adverse health effects in mice as monitored by diet consumption, body-weight gain, and postural and behavioural changes.
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