[CAS NO. 817194-38-0] GSK180736A (GSK180736)
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PRODUCTS SPECIFICATIONS [817194-38-0]
Store
Catalog
SLK-S8489
Brand
Selleck
CAS
817194-38-0
DESCRIPTION [817194-38-0]
Overview
| MDL | MFCD30533616 |
|---|---|
| Molecular Weight | 365.36 |
| Molecular Formula | C19H16FN5O2 |
| SMILES | O=C(C1=C(C)NC(NC1C2=CC=C(F)C=C2)=O)NC3=CC4=C(NN=C4)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7370 mL | 13.6851 mL | 27.3703 mL |
| 5 mM | 0.5474 mL | 2.7370 mL | 5.4741 mL |
| 10 mM | 0.2737 mL | 1.3685 mL | 2.7370 mL |
| 50 mM | 0.0547 mL | 0.2737 mL | 0.5474 mL |
Description
GSK180736A (GSK180736), developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5.
In vitro
GSK180736A exhibits a 770 nM IC50 value against GRK2 and 300-fold less potency against GRK5. It is a weak inhibitor of PKA with an IC50 of 30 μM, but highly potent against ROCK1 (IC50 = 100 nM).
References
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