[CAS NO. 2097262-58-1] TVB-3664
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PRODUCTS SPECIFICATIONS [2097262-58-1]
Store
Catalog
SLK-S8563
Brand
Selleck
CAS
2097262-58-1
DESCRIPTION [2097262-58-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 468.47 |
| Molecular Formula | C25H23F3N4O2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1346 mL | 10.6730 mL | 21.3461 mL |
| 5 mM | 0.4269 mL | 2.1346 mL | 4.2692 mL |
| 10 mM | 0.2135 mL | 1.0673 mL | 2.1346 mL |
| 50 mM | 0.0427 mL | 0.2135 mL | 0.4269 mL |
Description
TVB-3664 is a potent, selective, orally active and reversible inhibitor of with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.
Targets
In vitro
TVB-3664 induces FASN inhibition with significantly reduced tubulin palmitoylation and mRNA expression. Disrupted microtubule organization in tumor cells is an additional consequence of FASN inhibition. TVB-3664 combined with taxane treatment enhances inhibition of in vitro tumor cell growth compared to treatmentwith either agent alone.
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