[CAS NO. 1445879-21-9] GSK 2837808A
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PRODUCTS SPECIFICATIONS [1445879-21-9]
Store
Catalog
SLK-S8590
Brand
Selleck
CAS
1445879-21-9
DESCRIPTION [1445879-21-9]
Overview
| MDL | MFCD28133406 |
|---|---|
| Molecular Weight | 649.62 |
| Molecular Formula | C31H25F2N5O7S |
| SMILES | O=C(O)C1=CC(OC2=CC(F)=CC(F)=C2)=CC(NC3=C(S(=O)(NC4CC4)=O)C=NC5=CC(C6=CN=C(OC)N=C6OC)=CC=C35)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5394 mL | 7.6968 mL | 15.3936 mL |
| 5 mM | 0.3079 mL | 1.5394 mL | 3.0787 mL |
| 10 mM | 0.1539 mL | 0.7697 mL | 1.5394 mL |
| 50 mM | 0.0308 mL | 0.1539 mL | 0.3079 mL |
Description
GSK2837808A is a selective inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.
In vitro
GSK 2837808A rapidly and profoundly inhibits lactate production rates in multiple cancer cell lines including hepatocellular and breast carcinomas. GSK 2837808A increases rates of oxygen consumption in hepatocellular carcinoma cells at dose up to 3 microM, while higher concentrations directly inhibits mitochondrial function. GSK 2837808A dose dependently potentiates PKM2 activity, inhibits proliferation of Snu398 cells and induces apoptosis in Snu398 cells.
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