[CAS NO. 1446261-44-4] Pamiparib (BGB-290)
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PRODUCTS SPECIFICATIONS [1446261-44-4]
Store
Catalog
SLK-S8592
Brand
Selleck
CAS
1446261-44-4
DESCRIPTION [1446261-44-4]
Overview
| MDL | MFCD30489383 |
|---|---|
| Molecular Weight | 298.31 |
| Molecular Formula | C16H15FN4O |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3522 mL | 16.7611 mL | 33.5222 mL |
| 5 mM | 0.6704 mL | 3.3522 mL | 6.7044 mL |
| 10 mM | 0.3352 mL | 1.6761 mL | 3.3522 mL |
| 50 mM | 0.0670 mL | 0.3352 mL | 0.6704 mL |
Description
Pamiparib (BGB-290) is a potent and selective inhibitor of and with IC50 values of 0.83 and 0.11 nM, respectively in biochemical assays. It shows high selectivity over other PARP enzymes.
In vitro
BGB-290 shows potent DNA-trapping activity with IC50 of 13 nM. In the cellular assays, BGB-290 inhibits intracellular PAR formation with an IC50 of 0.24 nM.
References
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