[CAS NO. 150915-40-5] Tirofiban Hydrochloride

Name: Tirofiban Hydrochloride
Brand: Arctom Scientific
SKU: SLK-S8594

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PRODUCTS SPECIFICATIONS [150915-40-5]

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Catalog

SLK-S8594

Brand

Selleck

CAS

150915-40-5

DESCRIPTION [150915-40-5]

Overview

MDL	MFCD07368623
Molecular Weight	495.07
Molecular Formula	C22H36N2O5S.HCl.H2O
SMILES	C([C@H](NS(CCCC)(=O)=O)C(O)=O)C1=CC=C(OCCCCC2CCNCC2)C=C1.Cl.O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.0199 mL	10.0996 mL	20.1992 mL
5 mM	0.4040 mL	2.0199 mL	4.0398 mL
10 mM	0.2020 mL	1.0100 mL	2.0199 mL
50 mM	0.0404 mL	0.2020 mL	0.4040 mL

Description

Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of , a selective antagonist which inhibits . It is more soluable than Tirofiban.

Targets

GPIIb/IIIa ^[1]

In vitro

Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L.

References

[1] Hartman GD, et al. J Med Chem, 1992, 35(24), 4640-4642
[2] Egbertson MS, et al. J Med Chem, 1994, 37(16), 2537-2551.
[3] Lynch JJ Jr, et al. J Pharmacol Exp Ther, 1995, 272(1), 20-32.
[4] Barrett JS, et al. Clin Pharmacol Ther, 1994, 56(4), 377-388.
[5] Peerlinck K, et al. Circulation, 1993, 88(4 Pt 1), 1512-1517.

Synonyms

L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride, hydrate (1:1:1)

L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, monohydrochloride, monohydrate

Tirofiban hydrochloride monohydrate