[CAS NO. 1644443-47-9] Autophinib
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PRODUCTS SPECIFICATIONS [1644443-47-9]
Store
Catalog
SLK-S8596
Brand
Selleck
CAS
1644443-47-9
DESCRIPTION [1644443-47-9]
Overview
| MDL | MFCD31560472 |
|---|---|
| Molecular Weight | 346.73 |
| Molecular Formula | C14H11ClN6O3 |
| SMILES | O=[N+](C1=CC=C(OC2=NC(Cl)=CC(NC3=NNC(C)=C3)=N2)C=C1)[O-] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8841 mL | 14.4204 mL | 28.8409 mL |
| 5 mM | 0.5768 mL | 2.8841 mL | 5.7682 mL |
| 10 mM | 0.2884 mL | 1.4420 mL | 2.8841 mL |
| 50 mM | - | - | - |
Description
Autophinib is a potent inhibitor with a novel chemotype with values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for is 19 nM in vitro.
In vitro
Autophinib inhibits the accumulation of autophagosomes under fed as well as starved conditions, but does not affect the number of autolysosomes. Thus it is not a late stage autophagy inhibitor but an inhibitor of autophagosome formation. Autophinib targets VPS34 but not other lipid kinases, mTOR and TBK1. Autophinib appears to be ATP-competitive, targets VPS34 in cell lysate and induces cellular phenotypes consistent with VPS34 inhibition.
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