[CAS NO. 94164-88-2] PKM2 inhibitor(compound 3k)
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PRODUCTS SPECIFICATIONS [94164-88-2]
Store
Catalog
SLK-S8616
Brand
Selleck
CAS
94164-88-2
DESCRIPTION [94164-88-2]
Overview
| MDL | MFCD31619244 |
|---|---|
| Molecular Weight | 345.48 |
| Molecular Formula | C18H19NO2S2 |
| SMILES | S=C(N1CCCCC1)SCC(C2=O)=C(C)C(C3=C2C=CC=C3)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8945 mL | 14.4726 mL | 28.9452 mL |
| 5 mM | 0.5789 mL | 2.8945 mL | 5.7890 mL |
| 10 mM | 0.2895 mL | 1.4473 mL | 2.8945 mL |
| 50 mM | - | - | - |
Description
PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
Targets
| PKM2 [1] (Cell-free assay) |
| 2.95 μM |
In vitro
The well performing compound 3k shows nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18-1.56 μM. Moreover, compound 3k exhibits more cytotoxicity on cancer cells than normal cells.
References
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