[CAS NO. 157-03-9] 6-Diazo-5-oxo-L-norleucine

Name: 6-Diazo-5-oxo-L-norleucine
Brand: Arctom Scientific
SKU: SLK-S8620

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PRODUCTS SPECIFICATIONS [157-03-9]

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Catalog

SLK-S8620

Brand

Selleck

CAS

157-03-9

DESCRIPTION [157-03-9]

Overview

MDL	-
Molecular Weight	171.15
Molecular Formula	C6H9N3O3
SMILES	C(C[C@@H](C(O)=O)N)C(C=[N+]=[N-])=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	5.8428 mL	29.2141 mL	58.4283 mL
5 mM	1.1686 mL	5.8428 mL	11.6857 mL
10 mM	0.5843 mL	2.9214 mL	5.8428 mL
50 mM	0.1169 mL	0.5843 mL	1.1686 mL

Description

6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON), an antibiotic isolated from Streptomyces, is a antagonist with IC50 of ~1 mM for cKGA (kidney-type glutaminase). 6-Diazo-5-oxo-L-norleucine exhibits analgesic, antibacterial, antiviral and anticancer properties.

Targets

cKGA ^[1]
(Cell-free assay)

1 mM

In vitro

6-Diazo-5-oxo-L-norleucine appears to be positive in the in vitro chromosome aberration assay that it demonstrates dose dependent statistically positive increase in structural aberrations at 4 and 20 hour exposure without S9 and also at 4 hour exposure with S9.

References

[1] K Thangavelu, et al. Sci Rep. 2014 Jan 23;4:3827.
[2] Rohan M Kulkarni, et al. Toxicol Mech Methods. 2017 Sep;27(7):518-527.

Synonyms

L-Norleucine, 6-diazo-5-oxo-

Norleucine, 6-diazo-5-oxo-, L-

6-Diazo-5-oxo-L-norleucine

DON

NSC 7365

DON (pharmaceutical)

L-DON

L-6-Diazo-5-oxonorleucine

(2S)-2-Amino-6-diazo-5-oxohexanoic acid