[CAS NO. 887686-02-4] OSS_128167
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PRODUCTS SPECIFICATIONS [887686-02-4]
Store
Catalog
SLK-S8627
Brand
Selleck
CAS
887686-02-4
DESCRIPTION [887686-02-4]
Overview
| MDL | MFCD07114226 |
|---|---|
| Molecular Weight | 366.32 |
| Molecular Formula | C19H14N2O6 |
| SMILES | O=C(O)C1=CC(NC(C2=CC=CC(NC(C3=CC=CO3)=O)=C2)=O)=CC=C1O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
OSS_128167 (SIRT6-IN-1) is a specific inhibitor with values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
In vitro
OSS-128167 is a selective compounds toward SIRT6 with IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. OSS-128167 increases H3K9 acetylation and GLUT-1 expression.
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