[CAS NO. 1219739-36-2] ex229 (compound 991)
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PRODUCTS SPECIFICATIONS [1219739-36-2]
Store
Catalog
SLK-S8654
Brand
Selleck
CAS
1219739-36-2
DESCRIPTION [1219739-36-2]
Overview
| MDL | MFCD31696597 |
|---|---|
| Molecular Weight | 431.87 |
| Molecular Formula | C24H18ClN3O3 |
| SMILES | O=C(C1=CC(OC2=NC3=CC(C4=CC5=C(C=C4)N(C=C5)C)=C(C=C3N2)Cl)=CC=C1C)O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
EX229 (compound 991) is a potent activator that is 5-10-fold more potent than A769662 in activating AMPK.
Targets
| AMPK [1] |
In vitro
EX229 activates AMPK in incubated rat epitrochlearis skeletal muscle and incubation of rat skeletal muscle with ex229 increases glucose uptake. The stimulation of skeletal muscle glucose uptake by ex229 is PI3K/PKB-independent, while AMPK-dependent. ex229 increases fatty acid oxidation and glucose uptake in L6 myotubes.
References
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