[CAS NO. 5465-86-1] ML204

Name: ML204
Brand: Arctom Scientific
SKU: SLK-S8691

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PRODUCTS SPECIFICATIONS [5465-86-1]

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Catalog

SLK-S8691

Brand

Selleck

CAS

5465-86-1

DESCRIPTION [5465-86-1]

Overview

MDL	MFCD00817920
Molecular Weight	226.32
Molecular Formula	C15H18N2
SMILES	CC=1C2=C(N=C(C1)N3CCCCC3)C=CC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.4185 mL	22.0926 mL	44.1852 mL
5 mM	0.8837 mL	4.4185 mL	8.8370 mL
10 mM	0.4419 mL	2.2093 mL	4.4185 mL
50 mM	0.0884 mL	0.4419 mL	0.8837 mL

Description

ML204 is a novel, potent, and selective channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels.

Targets

TRPC4 ^[1]

In vitro

ML204 inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96 μM and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. ML204 block of TRPC4β channels is not dependent upon GPCR activation. Selectivity studies show no appreciable block by 10-20 μM ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons. ML204 blocks TRPC4β activity induced through either G stimulation by μ-opioid, 5HT1A serotonin, and M2 muscarinic receptors or G stimulation by the endogenous M3-like muscarinic receptors.

References

[1] Miller M, et al. J Biol Chem. 2011, 286(38):33436-46.

Synonyms

Quinoline, 4-methyl-2-(1-piperidinyl)-

Lepidine, 2-piperidino-

4-Methyl-2-(1-piperidinyl)quinoline

NSC 25850

ML 204