[CAS NO. 2097416-76-5] AZD0364 (ATG-017)
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PRODUCTS SPECIFICATIONS [2097416-76-5]
Store
Catalog
SLK-S8708
Brand
Selleck
CAS
2097416-76-5
DESCRIPTION [2097416-76-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 494.50 |
| Molecular Formula | C24H24F2N8O2 |
| SMILES | O=C1C2=NC(C3=NC(NC4=CC=NN4C)=NC=C3C)=CN2C[C@H](COC)N1CC5=CC=C(F)C(F)=C5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0222 mL | 10.1112 mL | 20.2224 mL |
| 5 mM | 0.4044 mL | 2.0222 mL | 4.0445 mL |
| 10 mM | 0.2022 mL | 1.0111 mL | 2.0222 mL |
| 50 mM | 0.0404 mL | 0.2022 mL | 0.4044 mL |
Description
AZD0364 (ATG-017) is a pre-clinical inhibitor with an IC50 of 0.6 nM for ERK2.
Targets
| ERK2 [1] |
| 0.6 nM |
In vitro
AZD0364 exhibits high cellular potency against a direct downstream substrate on the MAPK pathway (e.g. inhibition of phospho-p90RSK1 in BRAFV600E mutant A375 cells, IC50 = 6 nM). The molecule is a highly selective kinase inhibitor (10/329 kinases tested are inhibited at >50% at a 1 µM) and has long residence time on the protein (as determined by SPR on human unphosphorylated-ERK2: pKd = 10; t1/2 = 277 mins).
References
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