[CAS NO. 2172651-73-7] RMC-4550
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PRODUCTS SPECIFICATIONS [2172651-73-7]
Store
Catalog
SLK-S8718
Brand
Selleck
CAS
2172651-73-7
DESCRIPTION [2172651-73-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 437.36 |
| Molecular Formula | C21H26Cl2N4O2 |
| SMILES | OCC1=NC(C2=CC=CC(Cl)=C2Cl)=C(C)N=C1N(CC3)CCC43[C@H](N)[C@H](C)OC4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2864 mL | 11.4322 mL | 22.8645 mL |
| 5 mM | 0.4573 mL | 2.2864 mL | 4.5729 mL |
| 10 mM | 0.2286 mL | 1.1432 mL | 2.2864 mL |
| 50 mM | 0.0457 mL | 0.2286 mL | 0.4573 mL |
Description
RMC-4550 is a potent inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.
Targets
| SHP-2 [1] (Cell-free assay) |
| 1.55 nM |
In vitro
RMC-4550 inhibits purified, activated full length human SHP2 with an IC50 of 1.55 nM, and has cellular IC50 of 39 nM in PC9 cells with a pERK readout. RMC-4550 has no detectable inhibitory activity up to 10 µM against the catalytic domain of SHP2, a panel of 14 additional protein phosphatases, and a panel of 468 protein kinases. RMC-4550 exhibits low to moderate cross species in vitro intrinsic clearance (3.6-24 µL/min/million cells) in hepatocytes, a high passive permeability (458 nm/s) and efflux ratio of 1.
References
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