[CAS NO. 1815580-06-3] SKLB-23bb
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PRODUCTS SPECIFICATIONS [1815580-06-3]
Store
Catalog
SLK-S8743
Brand
Selleck
CAS
1815580-06-3
DESCRIPTION [1815580-06-3]
Overview
| MDL | MFCD30533607 |
|---|---|
| Molecular Weight | 396.44 |
| Molecular Formula | C21H24N4O4 |
| SMILES | O=C(NO)CCCOC1=CC(N(C)C2=C3C=CC=CC3=NC(C)=N2)=CC=C1OC |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5224 mL | 12.6122 mL | 25.2245 mL |
| 5 mM | 0.5045 mL | 2.5224 mL | 5.0449 mL |
| 10 mM | 0.2522 mL | 1.2612 mL | 2.5224 mL |
| 50 mM | 0.0504 mL | 0.2522 mL | 0.5045 mL |
Description
SKLB-23bb is an orally bioavailable inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.
Targets
| HDAC6 [1] (Cell-based assay) |
| <100 nM |
In vitro
SKLB-23bb shows cytotoxic effects against a panel of solid and hematologic tumor cell lines at the low submicromolar level. In contrast to the reported HDAC6-selective inhibitors, SKLB-23bb is more efficient against solid tumor cells. SKLB-23bb selectively inhibits cellular HDAC6, but the antitumor activity of SKLB-23bb is independent of HDAC6. SKLB-23bb could bind to the colchicine site in β-tubulin and act as a microtubule polymerization inhibitor. It blocks tumor cell cycle at G2-M phase and triggers cellular apoptosis.
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