[CAS NO. 1354690-24-6] leniolisib (CDZ 173)
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PRODUCTS SPECIFICATIONS [1354690-24-6]
Store
Catalog
SLK-S8752
Brand
Selleck
CAS
1354690-24-6
DESCRIPTION [1354690-24-6]
Overview
| MDL | MFCD30470232 |
|---|---|
| Molecular Weight | 450.46 |
| Molecular Formula | C21H25F3N6O2 |
| SMILES | CCC(N1C[C@@H](NC2=C(CN(C3=CC(C(F)(F)F)=C(OC)N=C3)CC4)C4=NC=N2)CC1)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2200 mL | 11.0998 mL | 22.1995 mL |
| 5 mM | 0.4440 mL | 2.2200 mL | 4.4399 mL |
| 10 mM | 0.2220 mL | 1.1100 mL | 2.2200 mL |
| 50 mM | 0.0444 mL | 0.2220 mL | 0.4440 mL |
Description
Leniolisib (CDZ 173) is a potent selective inhibitor with of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.
Targets
In vitro
In vitro, CDZ173 inhibits a large spectrum of immune cell functions, as demonstrated in B and T cells, neutrophils, monocytes, basophils, plasmocytoid dendritic cells, and mast cells. CDZ173 showed no activity up to the highest test concentration when tested against CYP isoform assays (3A3, 2D9, 2D6, 2C9), a panel of ion channels (including hERG) and a protease panel. In a panel of 50 safety related targets (GPCRs, ion channels, transporters), CDZ173 only showed measurable activity for hPDE4D (IC50 = 4.7 μM) and 5HT2B (IC50 = 7.7 μM).
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