[CAS NO. 2131184-57-9] VU661013
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PRODUCTS SPECIFICATIONS [2131184-57-9]
Store
Catalog
SLK-S8758
Brand
Selleck
CAS
2131184-57-9
DESCRIPTION [2131184-57-9]
Overview
| MDL | MFCD31746898 |
|---|---|
| Molecular Weight | 712.66 |
| Molecular Formula | C39H39Cl2N5O4 |
| SMILES | O=C(C1=CC2=C(N(C)C=C2N3C(C(N4[C@H](C)C3)=C(CCCOC5=CC(C)=C(Cl)C(C)=C5)C6=C4C(C7=C(C)N(C)N=C7C)=C(Cl)C=C6)=O)C=C1)O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4032 mL | 7.0160 mL | 14.0319 mL |
| 5 mM | 0.2806 mL | 1.4032 mL | 2.8064 mL |
| 10 mM | 0.1403 mL | 0.7016 mL | 1.4032 mL |
| 50 mM | 0.0281 mL | 0.1403 mL | 0.2806 mL |
Description
VU661013 is a novel, potent, selective inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to in AML.
Targets
| MCL1 [1] (Cell-free assay) |
| 97 pM(Ki) |
In vitro
VU661013 is a novel, potent, selective MCL-1 inhibitor that de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML, and is active in venetoclax-resistant cells.
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