[CAS NO. 1236199-60-2] Tinostamustine(EDO-S101)
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [1236199-60-2]
Store
Catalog
SLK-S8769
Brand
Selleck
CAS
1236199-60-2
DESCRIPTION [1236199-60-2]
Overview
| MDL | MFCD28400036 |
|---|---|
| Molecular Weight | 415.36 |
| Molecular Formula | C19H28Cl2N4O2 |
| SMILES | O=C(NO)CCCCCCC1=NC2=CC(N(CCCl)CCCl)=CC=C2N1C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4076 mL | 12.0378 mL | 24.0755 mL |
| 5 mM | 0.4815 mL | 2.4076 mL | 4.8151 mL |
| 10 mM | 0.2408 mL | 1.2038 mL | 2.4076 mL |
| 50 mM | - | - | - |
Description
Tinostamustine(EDO-S101) is a first-in-class inhibitor with IC50 values of 9 nM, 9 nM, 25 nM and 107 nM for HDAC1, HDAC2, HDAC3 and HDAC8 (Class 1 HDACs) respectively and 6 nM, 72 nM for HDAC6 and HDAC10 (Class II HDACs).
Targets
In vitro
The IC50s of EDO-S101 range between 5-13 μM in 8 myeloma cell lines. EDO-S101 has significant synergistic cytotoxicity with the proteasome inhibitors bortezomib and carfilzomib across all cell types tested. EDO-S101 induces strong protein and histone acetylation and is a strong inducer of pIRE-1, the key activator protein of the UPR in MM cells.
References
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.