[CAS NO. 927961-18-0] Lanifibranor (IVA-337)
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PRODUCTS SPECIFICATIONS [927961-18-0]
Store
Catalog
SLK-S8770
Brand
Selleck
CAS
927961-18-0
DESCRIPTION [927961-18-0]
Overview
| MDL | MFCD31619253 |
|---|---|
| Molecular Weight | 434.92 |
| Molecular Formula | C19H15ClN2O4S2 |
| SMILES | O=C(O)CCCC(N1S(=O)(C2=CC=C3N=CSC3=C2)=O)=CC4=C1C=CC(Cl)=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2993 mL | 11.4964 mL | 22.9927 mL |
| 5 mM | 0.4599 mL | 2.2993 mL | 4.5985 mL |
| 10 mM | 0.2299 mL | 1.1496 mL | 2.2993 mL |
| 50 mM | 0.0460 mL | 0.2299 mL | 0.4599 mL |
Description
Lanifibranor (IVA-337) is a moderately potent and well balanced pan agonist with of 1537 nM, 866 nM and 206 nM for hPPARα, hPPARδ and hPPARγ, respectively.
In vitro
IVA337 acts as a pan‐PPAR agonist with moderate and balanced activity on the three PPAR isoforms. IVA337 50% effective concentration (EC50) levels for the human PPARs (hPPARs) were 1.63E-06 M for PPARα, 8.49E-07 M for PPARδ, and 2.28E-07 M for PPARγ. IVA337 EC50 levels for the rodent PPARs were 3.78E-07 M for PPARα, 1.55E-06 M for PPARδ, and 2.23E-07 M for PPARγ. IVA337 inhibits PDGF-induced proliferation, stiffness-induced activation, and TGF-β1-induced overexpression of fibrotic genes in hHSCs (human primary hepatic stellate cells).
References
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