[CAS NO. 2247481-21-4] JSH-150
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PRODUCTS SPECIFICATIONS [2247481-21-4]
Store
Catalog
SLK-S8783
Brand
Selleck
CAS
2247481-21-4
DESCRIPTION [2247481-21-4]
Overview
| MDL | MFCD31807311 |
|---|---|
| Molecular Weight | 505.08 |
| Molecular Formula | C24H33ClN6O2S |
| SMILES | N#CC1(CNC2=NC(C3=CC(N[C@H]4CC[C@H](NCCOC)CC4)=NC=C3Cl)=CS2)CCOCC1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9799 mL | 9.8994 mL | 19.7988 mL |
| 5 mM | 0.3960 mL | 1.9799 mL | 3.9598 mL |
| 10 mM | 0.1980 mL | 0.9899 mL | 1.9799 mL |
| 50 mM | 0.0396 mL | 0.1980 mL | 0.3960 mL |
Description
JSH-150 is a highly selective and potent inhibitor of with IC50 of 1 nM.
Targets
| CDK9 [1] (Cell-free assay) |
| 1 nM |
In vitro
JSH-150 exhibits an IC50 of 1 nM against CDK9 kinase in the biochemical assay and achieves around 300-10000-fold selectivity over other CDK kinase family members. In addition, it also displays high selectivity over other 468 kinases/mutants. JSH-150 displays potent antiproliferative effects against melanoma, neuroblastoma, hepatoma, colon cancer, lung cancer as well as leukemia cell lines. It can dose-dependently inhibit the phosphorylation of RNA Pol II, suppress the expression of MCL-1 and C-Myc, arrest the cell cycle and induce the apoptosis in the leukemia cells.
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