[CAS NO. 1927857-56-4] PQR620
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PRODUCTS SPECIFICATIONS [1927857-56-4]
Store
Catalog
SLK-S8784
Brand
Selleck
CAS
1927857-56-4
DESCRIPTION [1927857-56-4]
Overview
| MDL | MFCD30489733 |
|---|---|
| Molecular Weight | 445.47 |
| Molecular Formula | C21H25F2N7O2 |
| SMILES | NC1=NC=C(C2=NC(N3[C@@]4([H])COC[C@]3([H])CC4)=NC(N5[C@@]6([H])COC[C@]5([H])CC6)=N2)C(C(F)F)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2448 mL | 11.2241 mL | 22.4482 mL |
| 5 mM | 0.4490 mL | 2.2448 mL | 4.4896 mL |
| 10 mM | 0.2245 mL | 1.1224 mL | 2.2448 mL |
| 50 mM | - | - | - |
Description
PQR620 is a novel, selective, orally bioavailable and brain penetrant dual inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.
In vitro
PQR620 is a novel brain penetrant dual TORC1/2 inhibitor with anti-tumor activity across 56 lymphoma cell lines with a median IC50 value of 250 nM after 72 h of exposure.
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