[CAS NO. 2064292-12-0] A1874
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PRODUCTS SPECIFICATIONS [2064292-12-0]
Store
Catalog
SLK-S8785
Brand
Selleck
CAS
2064292-12-0
DESCRIPTION [2064292-12-0]
Overview
| MDL | MFCD31813733 |
|---|---|
| Molecular Weight | 1173.59 |
| Molecular Formula | C58H62Cl3F2N9O7S |
| SMILES | O=C(NCCOCCOCCOCCNC(C1=CC=C(NC([C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(C3=CC=C(Cl)C=C3F)[C@H]2C4=CC=CC(Cl)=C4F)=O)C(OC)=C1)=O)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.8521 mL | 4.2604 mL | 8.5209 mL |
| 5 mM | 0.1704 mL | 0.8521 mL | 1.7042 mL |
| 10 mM | 0.0852 mL | 0.4260 mL | 0.8521 mL |
| 50 mM | 0.0170 mL | 0.0852 mL | 0.1704 mL |
Description
A1874 is a much improved nutlin-based, and is able to degrade its target protein by 98% with nanomolar potency.
Targets
| BRD4 [1] |
In vitro
In HCT116 cells, A1874 causes a 97% decrease in viability and in A375 cells, A1874 causes a 98% loss of viability.A1874 reduced viability of Daudi cells by 70% and of MOLM-13 cells by 95%.
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