[CAS NO. 1691249-45-2] Zanubrutinib (BGB-3111)
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PRODUCTS SPECIFICATIONS [1691249-45-2]
Store
Catalog
SLK-S8791
Brand
Selleck
CAS
1691249-45-2
DESCRIPTION [1691249-45-2]
Overview
| MDL | MFCD31567461 |
|---|---|
| Molecular Weight | 471.55 |
| Molecular Formula | C27H29N5O3 |
| SMILES | C(N)(=O)C1=C2N([C@@](CCN2)(C3CCN(C(C=C)=O)CC3)[H])N=C1C4=CC=C(OC5=CC=CC=C5)C=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1207 mL | 10.6033 mL | 21.2067 mL |
| 5 mM | 0.4241 mL | 2.1207 mL | 4.2413 mL |
| 10 mM | 0.2121 mL | 1.0603 mL | 2.1207 mL |
| 50 mM | 0.0424 mL | 0.2121 mL | 0.4241 mL |
Description
Zanubrutinib (BGB-3111) is a potent, specific and irreversible inhibitor that has been shown to have a lower off-target inhibitory activity on other kinases, including ITK, JAK3 and EGFR.
Targets
| BTK [1] (Cell-free assay) |
In vitro
In biochemical and cellular assays, BGB-3111 is more selective than ibrutinib for BTK vs. EGFR, FGR, FRK, HER2, HER4, ITK, JAK3, LCK, BLK and TEC.In several MCL and DLBCL cell lines, BGB-3111 inhibits BCR aggregation-triggered BTK autophosphorylation, blocks downstream PLC-γ2 signaling, and potently inhibits cell proliferation.
References
Synonyms
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)-, (7S)-
(7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Zanubrutinib
Brukinsa
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