[CAS NO. 2361493-16-3] BSJ-03-123
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PRODUCTS SPECIFICATIONS [2361493-16-3]
Store
Catalog
SLK-S8815
Brand
Selleck
CAS
2361493-16-3
DESCRIPTION [2361493-16-3]
Overview
| MDL | MFCD31813815 |
|---|---|
| Molecular Weight | 937.01 |
| Molecular Formula | C47H56N10O11 |
| SMILES | O=C(CCC1N2C(C(C=CC=C3OCC(NCCOCCOCCOCCN4CCN(C5=CC=C(NC6=NC(N(C7CCCC7)C(C(C(C)=O)=C8C)=O)=C8C=N6)N=C5)CC4)=O)=C3C2=O)=O)NC1=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.0672 mL | 5.3361 mL | 10.6722 mL |
| 5 mM | 0.2134 mL | 1.0672 mL | 2.1344 mL |
| 10 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL |
| 50 mM | 0.0213 mL | 0.1067 mL | 0.2134 mL |
Description
BSJ-03-123 is a phthalimide-based degrader of . (PROTAC)
Targets
| CDK6 [1] |
In vitro
BSJ-03-123 is a phthalimide-based degrader that exploits protein-interface determinants to achieve proteome-wide selectivity for the degradation of cyclin-dependent kinase 6 (CDK6). Pharmacologic CDK6 degradation targets a selective dependency of acute myeloid leukemia cells, and transcriptomics and phosphoproteomics profiling of acute degradation of CDK6 enabled dynamic mapping of its immediate role in coordinating signaling and transcription.
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