[CAS NO. 1627856-64-7] GSK3179106
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PRODUCTS SPECIFICATIONS [1627856-64-7]
Store
Catalog
SLK-S8821
Brand
Selleck
CAS
1627856-64-7
DESCRIPTION [1627856-64-7]
Overview
| MDL | MFCD30747847 |
|---|---|
| Molecular Weight | 467.41 |
| Molecular Formula | C22H21F4N3O4 |
| SMILES | O=C(NC1=NOC(C(C)(C)C(F)(F)F)=C1)CC2=CC=C(C(C(OCC)=C3)=CNC3=O)C=C2F |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1394 mL | 10.6972 mL | 21.3945 mL |
| 5 mM | 0.4279 mL | 2.1394 mL | 4.2789 mL |
| 10 mM | 0.2139 mL | 1.0697 mL | 2.1394 mL |
| 50 mM | 0.0428 mL | 0.2139 mL | 0.4279 mL |
Description
GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo.
Targets
| RET [1] (Cell-free assay) |
| 0.3 nM |
In vitro
GSK3179106 has a clean genotoxic profile with no embedded genotoxicity liabilities and possesses good kinase selectivity: only 26 out of a set of >300 recombinant kinases are found to be inhibited at a 1 μM test concentration.
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