[CAS NO. 1446817-84-0] ABX-1431
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PRODUCTS SPECIFICATIONS [1446817-84-0]
Store
Catalog
SLK-S8823
Brand
Selleck
CAS
1446817-84-0
DESCRIPTION [1446817-84-0]
Overview
| MDL | MFCD31735112 |
|---|---|
| Molecular Weight | 507.39 |
| Molecular Formula | C20H22F9N3O2 |
| SMILES | O=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2N3CCCC3)CC1)OC(C(F)(F)F)C(F)(F)F |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9709 mL | 9.8544 mL | 19.7087 mL |
| 5 mM | 0.3942 mL | 1.9709 mL | 3.9417 mL |
| 10 mM | 0.1971 mL | 0.9854 mL | 1.9709 mL |
| 50 mM | 0.0394 mL | 0.1971 mL | 0.3942 mL |
Description
ABX-1431 is a highly potent, selective, and CNS-penetrant inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.
In vitro
ABX-1431 is a potent human MGLL inhibitor (average IC50 = 0.014 μM) with >100-fold selectivity against ABHD6 and >200-fold selectivity against PLA2G7. Treatment of intact human PC3 cells with ABX-1431 following a 30 min inhibitor incubation time causes concentration dependent inhibition of MGLL activity with an IC50 value of 0.0022 μM, which is ∼6-fold more potent than that observed in vitro. ABX-1431 inhibits MGLL via carbamoylation of the catalytic nucleophile Ser122.
References
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