[CAS NO. 2101315-36-8] Gboxin

Name: Gboxin
Brand: Arctom Scientific
SKU: SLK-S8828

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PRODUCTS SPECIFICATIONS [2101315-36-8]

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Catalog

SLK-S8828

Brand

Selleck

CAS

2101315-36-8

DESCRIPTION [2101315-36-8]

Overview

MDL	-
Molecular Weight	392.96
Molecular Formula	C22H33ClN2O2
SMILES	C(C(O[C@H]1[C@H]([C@@H](C)C)CC[C@@H](C)C1)=O)[N+]=2C=3C(N(C)C2CC)=CC=CC3.[Cl-]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5448 mL	12.7239 mL	25.4479 mL
5 mM	0.5090 mL	2.5448 mL	5.0896 mL
10 mM	0.2545 mL	1.2724 mL	2.5448 mL
50 mM	0.0509 mL	0.2545 mL	0.5090 mL

Description

Gboxin is an inhibitor of in cancer cells. Gboxin inhibits the activity of . It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.

Targets

oxidative phosphorylation ^[1]

F0F1 ATP synthase ^[1]

In vitro

Gboxin rapidly and irreversibly compromises GBM oxygen consumption. Reliant on its positive charge, Gboxin associates with mitochondrial oxidative phosphorylation complexes in a proton gradient dependent manner and inhibits F0F1 ATP synthase activity. Gboxin targets unique features of mitochondrial pH in GBM and other cancer cells, independent of their genetic composition, and exerts its tumor cell specific toxicity in primary culture and in vivo.

References

[1] Shi Y, et al. Nature. 2019, 567(7748):341-346.

Synonyms

1H-Benzimidazolium, 2-ethyl-1-methyl-3-[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-2-oxoethyl]-, chloride (1:1)