[CAS NO. 1858276-04-6] Subasumstat (TAK-981)
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PRODUCTS SPECIFICATIONS [1858276-04-6]
Store
Catalog
SLK-S8829
Brand
Selleck
CAS
1858276-04-6
DESCRIPTION [1858276-04-6]
Overview
| MDL | MFCD32062692 |
|---|---|
| Molecular Weight | 578.10 |
| Molecular Formula | C25H28ClN5O5S2 |
| SMILES | O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=CC([C@@H]4NCCC5=C4C=C(Cl)C=C5)=C(C)S3)=O)C1)(N)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7298 mL | 8.6490 mL | 17.2980 mL |
| 5 mM | 0.3460 mL | 1.7298 mL | 3.4596 mL |
| 10 mM | 0.1730 mL | 0.8649 mL | 1.7298 mL |
| 50 mM | 0.0346 mL | 0.1730 mL | 0.3460 mL |
Description
Subasumstat (TAK-981) is a novel, selective inhibitor of the with potential immune-activating and antineoplastic activities.
Targets
| SUMOylation enzymatic cascade [1] |
In vitro
In both mouse bone-marrow and human peripheral blood mononuclear cell derived dendritic cells (DCs), TAK-981 treatment ex vivo induced markers of activation and maturation including CD40, CD80 and CD86, as well as increased secretion of inflammatory cytokines like IP-10, MCP1, MIP-1α, MIP1β, IFNα and IFNβ.
References
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