[CAS NO. 2296729-00-3] Sotorasib (AMG510)
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PRODUCTS SPECIFICATIONS [2296729-00-3]
Store
Catalog
SLK-S8830
Brand
Selleck
CAS
2296729-00-3
DESCRIPTION [2296729-00-3]
Overview
| MDL | MFCD32062763 |
|---|---|
| Molecular Weight | 560.59 |
| Molecular Formula | C30H30F2N6O3 |
| SMILES | O=C1N(C2=C(C)C=CN=C2C(C)C)C3=NC(C4=C(O)C=CC=C4F)=C(F)C=C3C(N5[C@@H](C)CN(C(C=C)=O)CC5)=N1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7838 mL | 8.9192 mL | 17.8383 mL |
| 5 mM | 0.3568 mL | 1.7838 mL | 3.5677 mL |
| 10 mM | 0.1784 mL | 0.8919 mL | 1.7838 mL |
| 50 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL |
Description
Sotorasib (AMG510) is a potent covalent inhibitor with potential antineoplastic activity.
Targets
| K-Ras(G12C) [1] |
In vitro
AMG 510 inhibits SOS1-catalyzed nucleotide exchange of recombinant mutant KRAS (G12C/C118A) but had minimal effect on KRAS (C118A). AMG 510 also selectively impairs the viability of KRAS p.G12C mutant lines but does not affect cell lines with other KRAS mutations.
References
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