[CAS NO. 1912445-55-6] Branebrutinib (BMS-986195)
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PRODUCTS SPECIFICATIONS [1912445-55-6]
Store
Catalog
SLK-S8832
Brand
Selleck
CAS
1912445-55-6
DESCRIPTION [1912445-55-6]
Overview
| MDL | MFCD31631584 |
|---|---|
| Molecular Weight | 370.42 |
| Molecular Formula | C20H23FN4O2 |
| SMILES | O=C(C1=CC(F)=C(N2C[C@@H](NC(C#CC)=O)CCC2)C3=C1NC(C)=C3C)N |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6996 mL | 13.4982 mL | 26.9964 mL |
| 5 mM | 0.5399 mL | 2.6996 mL | 5.3993 mL |
| 10 mM | 0.2700 mL | 1.3498 mL | 2.6996 mL |
| 50 mM | 0.0540 mL | 0.2700 mL | 0.5399 mL |
Description
Branebrutinib (BMS-986195) is a potent inhibitor of with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively.
Targets
In vitro
In human whole blood assays, BMS-986195 potently inhibited BCR-stimulated expression of CD69 on B cells with an IC50 of 11 nM. BMS-986195 is highly selective, providing >5,000-fold selectivity for BTK over 240 kinases with only the 4 related Tec family kinases demonstrating less than 5000-fold selectivity (9 - 1,000-fold).
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