[CAS NO. 2227587-26-8] GSK3368715 (EPZ019997) 3HCl
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PRODUCTS SPECIFICATIONS [2227587-26-8]
Store
Catalog
SLK-S8858
Brand
Selleck
CAS
2227587-26-8
DESCRIPTION [2227587-26-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 475.92 |
| Molecular Formula | C20H41Cl3N4O2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1012 mL | 10.5060 mL | 21.0119 mL |
| 5 mM | 0.4202 mL | 2.1012 mL | 4.2024 mL |
| 10 mM | 0.2101 mL | 1.0506 mL | 2.1012 mL |
| 50 mM | 0.0420 mL | 0.2101 mL | 0.4202 mL |
Description
GSK3368715 is a potent inhibitor of that inhibits PRMT1, 3, 4, 6 and 8 with Ki vaules ranging from 1.5 to 81 nM.
In vitro
GSK3368715 is a potent, reversible, SAM uncompetitive inhibitor of type I PRMTs that produces a shift in arginine methylation states on hundreds of substrates from ADMA to MMA and SDMA. As a monotherapy, GSK3368715 induces anti-proliferative effects on cell lines from a broad range of hematological and solid tumor types in vitro.
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