[CAS NO. 1818314-88-3] BMS-1166
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PRODUCTS SPECIFICATIONS [1818314-88-3]
Store
Catalog
SLK-S8859
Brand
Selleck
CAS
1818314-88-3
DESCRIPTION [1818314-88-3]
Overview
| MDL | MFCD31746874 |
|---|---|
| Molecular Weight | 641.11 |
| Molecular Formula | C36H33ClN2O7 |
| SMILES | O=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5598 mL | 7.7990 mL | 15.5979 mL |
| 5 mM | 0.3120 mL | 1.5598 mL | 3.1196 mL |
| 10 mM | 0.1560 mL | 0.7799 mL | 1.5598 mL |
| 50 mM | 0.0312 mL | 0.1560 mL | 0.3120 mL |
Description
BMS-1166 is a novel and potent small molecule inhibitor of the with an IC50 of 1.4 nM.
Targets
| PD-1/PD-L1 interaction [1] |
| 1.4 nM |
In vitro
BMS-1166 presents low toxicity towards tested cell lines and blocks the interaction of soluble PD-L1 with the cell surface-expressed PD-1. BMS-1166 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.
References
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