[CAS NO. 1315355-93-1] NG25

Name: NG25
Brand: Arctom Scientific
SKU: SLK-S8868

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PRODUCTS SPECIFICATIONS [1315355-93-1]

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Catalog

SLK-S8868

Brand

Selleck

CAS

1315355-93-1

DESCRIPTION [1315355-93-1]

Overview

MDL	MFCD19443255
Molecular Weight	537.58
Molecular Formula	C29H30F3N5O2
SMILES	O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(OC4=C5C(NC=C5)=NC=C4)=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

NG25 is a novel inhibitor of with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.

Targets

TAK1 ^[1]

MAP4K2 ^[1]

In vitro

NG25 can inhibit phosphorylation of proteins predicted to be downstream of TAK1 and MAP4K2 such as IKK, p38 and JNK at concentrations of less than 100 nM.

References

[1] Li Tan, et al. J Med Chem. 2015, 58(1): 183-196.
[2] Yoshimoto S, et al. Lab Invest. 2022 Jan;102(1):80-89.