[CAS NO. 917389-32-3] Letermovir (AIC246)
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PRODUCTS SPECIFICATIONS [917389-32-3]
Store
Catalog
SLK-S8873
Brand
Selleck
CAS
917389-32-3
DESCRIPTION [917389-32-3]
Overview
| MDL | MFCD22572725 |
|---|---|
| Molecular Weight | 572.55 |
| Molecular Formula | C29H28F4N4O4 |
| SMILES | C(C(O)=O)[C@@H]1N(C(=NC=2C1=CC=CC2F)N3CCN(CC3)C4=CC(OC)=CC=C4)C5=C(OC)C=CC(C(F)(F)F)=C5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7466 mL | 8.7329 mL | 17.4657 mL |
| 5 mM | 0.3493 mL | 1.7466 mL | 3.4931 mL |
| 10 mM | 0.1747 mL | 0.8733 mL | 1.7466 mL |
| 50 mM | 0.0349 mL | 0.1747 mL | 0.3493 mL |
Description
Letermovir (AIC246, MK-8228) is a novel compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
In vitro
AIC246 blocks viral replication without inhibiting the synthesis of progeny HCMV DNA or viral proteins. It is one of the most potent anti-HCMV agents reported to date, with a cell culture EC50 in the one-digit nanomolar range (∼5 nM) and a selectivity index exceeding 15,000.
References
Synonyms
4-Quinazolineacetic acid, 8-fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-, (4S)-
(4S)-8-Fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4-quinazolineacetic acid
AIC 246
Letermovir
Prevymis
(S)-2-(8-Fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid
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