[CAS NO. 1430723-35-5] ODM-203
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PRODUCTS SPECIFICATIONS [1430723-35-5]
Store
Catalog
SLK-S8882
Brand
Selleck
CAS
1430723-35-5
DESCRIPTION [1430723-35-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 505.54 |
| Molecular Formula | C26H21F2N5O2S |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9781 mL | 9.8904 mL | 19.7808 mL |
| 5 mM | 0.3956 mL | 1.9781 mL | 3.9562 mL |
| 10 mM | 0.1978 mL | 0.9890 mL | 1.9781 mL |
| 50 mM | 0.0396 mL | 0.1978 mL | 0.3956 mL |
Description
ODM-203 is a selective inhibitor of and with ic50s of 11 nM,16 nM,6 nM, 35 nM,26 nM,9 nM,5 nM for recombinant FGFR1, FGFR2, FGFR3,FGFR4, VEGFR1, VEGFR2 and VEGFR3, respectively.
Targets
In vitro
In cellular assays, ODM-203 inhibits VEGFR-induced tube formation (IC50 33 nmol/L) with similar potency as it inhibits proliferation in FGFR-dependent cell lines such as H1581,SNU16,and RT4 cells (IC50 50-150 nmol/L).
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