[CAS NO. 1797406-69-9] MZ-1
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PRODUCTS SPECIFICATIONS [1797406-69-9]
Store
Catalog
SLK-S8889
Brand
Selleck
CAS
1797406-69-9
DESCRIPTION [1797406-69-9]
Overview
| MDL | MFCD30742945 |
|---|---|
| Molecular Weight | 1002.64 |
| Molecular Formula | C49H60ClN9O8S2 |
| SMILES | O=C(NC([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1)=O)=O)=O)[C@H]5N(CC6=CC=C(C7=C(C)N=CS7)C=C6)C[C@H](O)C5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.9974 mL | 4.9868 mL | 9.9737 mL |
| 5 mM | 0.1995 mL | 0.9974 mL | 1.9947 mL |
| 10 mM | 0.0997 mL | 0.4987 mL | 0.9974 mL |
| 50 mM | 0.0199 mL | 0.0997 mL | 0.1995 mL |
Description
MZ-1 is a PROTAC degrader of . MZ-1 binds to the Brd bromodomain with Kd of 62 nM, 60 nM, 21 nM, 13 nM, 39 nM and 15 nM for Brd2, Brd2, Brd3, Brd3, Brd4 and Brd4.
Targets
In vitro
MZ-1 induces apoptosis of ovarian cancer cells and inhibits periostin-mediated ovarian cancer cell migration and invasion in vitro. MZ-1 specifically and efficiently inhibits the colony formation of periostin cells in soft agar, which clearly indicates a proproliferation role of periostin.
References
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