[CAS NO. 1434635-54-7] Firsocostat (GS-0976)
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PRODUCTS SPECIFICATIONS [1434635-54-7]
Store
Catalog
SLK-S8893
Brand
Selleck
CAS
1434635-54-7
DESCRIPTION [1434635-54-7]
Overview
| MDL | MFCD28963986 |
|---|---|
| Molecular Weight | 569.63 |
| Molecular Formula | C28H31N3O8S |
| SMILES | O=C(O)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC=CO5)S3)=O)C4=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7555 mL | 8.7776 mL | 17.5553 mL |
| 5 mM | 0.3511 mL | 1.7555 mL | 3.5111 mL |
| 10 mM | 0.1756 mL | 0.8778 mL | 1.7555 mL |
| 50 mM | 0.0351 mL | 0.1756 mL | 0.3511 mL |
Description
Firsocostat (GS-0976, NDI-010976, ND-630) is a reversible inhibitor of with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively.
In vitro
When ND-630 and [C]acetate were administered to Hep-G2 cells for 4 h, ND-630 inhibited FASyn with EC50 values of 66 nM in cells cultured in medium containing. When ND-630 and[C]palmitate were administered to C2C12 cells for 6 h, ND-630 increased both the release of [C]O and the production of[C]acid-soluble material.
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