[CAS NO. 2289690-31-7] MYCi361
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PRODUCTS SPECIFICATIONS [2289690-31-7]
Store
Catalog
SLK-S8905
Brand
Selleck
CAS
2289690-31-7
DESCRIPTION [2289690-31-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 594.86 |
| Molecular Formula | C26H16ClF9N2O2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6811 mL | 8.4053 mL | 16.8107 mL |
| 5 mM | 0.3362 mL | 1.6811 mL | 3.3621 mL |
| 10 mM | 0.1681 mL | 0.8405 mL | 1.6811 mL |
| 50 mM | 0.0336 mL | 0.1681 mL | 0.3362 mL |
Description
MYCi361 is a inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
Targets
| MYC [1] (Cell-free assay) |
| 3.2 μM(Kd) |
In vitro
MYCi361 engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 enhances MYC phosphorylation on threonine-58, consequently increasing proteasome-mediated MYC degradation.
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