[CAS NO. 358721-70-7] UBCS039
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PRODUCTS SPECIFICATIONS [358721-70-7]
Store
Catalog
SLK-S8909
Brand
Selleck
CAS
358721-70-7
DESCRIPTION [358721-70-7]
Overview
| MDL | MFCD00206184 |
|---|---|
| Molecular Weight | 247.29 |
| Molecular Formula | C16H13N3 |
| SMILES | C1(NC2=CC=CC=C2N3C=CC=C13)C4=CN=CC=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0438 mL | 20.2192 mL | 40.4384 mL |
| 5 mM | 0.8088 mL | 4.0438 mL | 8.0877 mL |
| 10 mM | 0.4044 mL | 2.0219 mL | 4.0438 mL |
| 50 mM | 0.0809 mL | 0.4044 mL | 0.8088 mL |
Description
UBCS039 is the first synthetic activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
Targets
| SIRT6 [1] (Cell-free assay) |
| 38 μM(EC50) |
In vitro
UBCS039 induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells.UBCS039 leads to autophagosome accumulation and induces autophagic flux in human cancer cells.UBCS039 also induces autophagy-associated cell death.
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