[CAS NO. 191282-48-1] C75 trans
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PRODUCTS SPECIFICATIONS [191282-48-1]
Store
Catalog
SLK-S8915
Brand
Selleck
CAS
191282-48-1
DESCRIPTION [191282-48-1]
Overview
| MDL | MFCD03265452 |
|---|---|
| Molecular Weight | 254.32 |
| Molecular Formula | C14H22O4 |
| SMILES | [C@@H]1(OC(=O)C(=C)[C@@H]1C(=O)O)CCCCCCCC |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9321 mL | 19.6603 mL | 39.3205 mL |
| 5 mM | 0.7864 mL | 3.9321 mL | 7.8641 mL |
| 10 mM | 0.3932 mL | 1.9660 mL | 3.9321 mL |
| 50 mM | 0.0786 mL | 0.3932 mL | 0.7864 mL |
Description
C75 trans (trans-C75, (±)-C75) is a novel, potent synthetic inhibitor of with IC50 of 35 μM and 50 μM in clonogenic assays and spheroid growth assay, respectively. C75 is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.
In vitro
C75 is toxic to prostate cancer cells. C75 reduces cell migration, while enhances radiation-induced clonogenic kill and enhances the spheroid growth delay induced by radiation exposure. Apoptosis induction by radiation exposure is enhanced by C75 treatment. C75 inhibits fatty acid synthesis and growth of established cancer cell lines from neu-N transgenic mice. C75 reduces the proliferation and expression of FAS, neu, and related genes in mammary epithelium.
References
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