[CAS NO. 2230836-55-0] BI-3406

Name: BI-3406
Brand: Arctom Scientific
SKU: SLK-S8916

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PRODUCTS SPECIFICATIONS [2230836-55-0]

Store

Catalog

SLK-S8916

Brand

Selleck

CAS

2230836-55-0

DESCRIPTION [2230836-55-0]

Overview

MDL	MFCD32197204
Molecular Weight	462.46
Molecular Formula	C23H25F3N4O3
SMILES	COC1=CC2=C(C(N[C@H](C)C3=CC(C(F)(F)F)=CC(N)=C3)=NC(C)=N2)C=C1O[C@@H]4COCC4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

BI-3406 (compound I-13) is a potent, selective and orally active inhibitor of the interaction between and with IC50 of 5 nM. BI-3406 reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 exhibits anti-tumor activities.

Targets

K-ras ^[1]
(Cell-free assay)

5 nM