[CAS NO. 2166616-75-5] LY-3381916
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PRODUCTS SPECIFICATIONS [2166616-75-5]
Store
Catalog
SLK-S8919
Brand
Selleck
CAS
2166616-75-5
DESCRIPTION [2166616-75-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 396.45 |
| Molecular Formula | C23H25FN2O3 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective inhibitor. LY-3381916 exhibits anti-tumor activity.
Targets
| IDO1 [1] |
In vitro
LY3381916 binds to newly synthesized apo-IDO1 lacking heme, but does not inhibit mature heme-bound IDO1. Protein x-ray crystallography confirms that LY3381916 binds to apo-IDO1 where it occupies the heme-binding pocket of IDO1. Modeling of the pre-clinical PK/PD relationship suggests QD dosing of LY3381916 will maintain greater than 90% inhibition over 24 hours. In addition, due to the favorable properties of the drug, significant central nervous system (CNS) penetration has been measured for LY3381916.
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