[CAS NO. 2140807-05-0] (Rac)-JBJ-04-125-02
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PRODUCTS SPECIFICATIONS [2140807-05-0]
Store
Catalog
SLK-S8920
Brand
Selleck
CAS
2140807-05-0
DESCRIPTION [2140807-05-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 543.61 |
| Molecular Formula | C29H26FN5O3S |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8396 mL | 9.1978 mL | 18.3955 mL |
| 5 mM | 0.3679 mL | 1.8396 mL | 3.6791 mL |
| 10 mM | 0.1840 mL | 0.9198 mL | 1.8396 mL |
| 50 mM | 0.0368 mL | 0.1840 mL | 0.3679 mL |
Description
(Rac)-JBJ-04-125-02 (JBJ-04-125-02 racemate) is a mutant-selective allosteric inhibitor of with potential anticancer activity.
Targets
| EGFR [1] |
In vitro
JBJ-04-125-02 can inhibit cell proliferation in vitro. Osimertinib, an ATP-competitive covalent EGFR inhibitor, uniquely and significantly enhances the binding of JBJ-04-125-02 for mutant EGFR. The combination of osimertinib and JBJ-04-125-02 results in an increase in apoptosis, a more effective inhibition of cellular growth in vitro compared to either single agent alone.
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