[CAS NO. 702662-50-8] STING agonist-1 (G10)
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PRODUCTS SPECIFICATIONS [702662-50-8]
Store
Catalog
SLK-S8954
Brand
Selleck
CAS
702662-50-8
DESCRIPTION [702662-50-8]
Overview
| MDL | MFCD04062826 |
|---|---|
| Molecular Weight | 430.88 |
| Molecular Formula | C21H16ClFN2O3S |
| SMILES | O=C(C1=CC=C(SCC(N2CC3=C(F)C=CC=C3Cl)=O)C2=C1)NCC4=CC=CO4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3208 mL | 11.6042 mL | 23.2083 mL |
| 5 mM | 0.4642 mL | 2.3208 mL | 4.6417 mL |
| 10 mM | 0.2321 mL | 1.1604 mL | 2.3208 mL |
| 50 mM | 0.0464 mL | 0.2321 mL | 0.4642 mL |
Description
STING agonist-1 (G10) is a novel human-specific agonist that triggers -associated transcription in human fibroblasts. STING agonist-1 (G10) potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 μM and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
In vitro
G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts. G10 elicits antiviral activity against New and Old World Alphaviruses. G10 induces STING-dependent synthesis and secretion of bioactive interferon. G10 triggers IRF3-dependent activity and induces innate antiviral mRNA expression in primary human cells.
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