[CAS NO. 1700637-55-3] CD38 inhibitor 1 (compound 78c)

Name: CD38 inhibitor 1 (compound 78c)
Brand: Arctom Scientific
SKU: SLK-S8960

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PRODUCTS SPECIFICATIONS [1700637-55-3]

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Catalog

SLK-S8960

Brand

Selleck

CAS

1700637-55-3

DESCRIPTION [1700637-55-3]

Overview

MDL	MFCD32062812
Molecular Weight	413.53
Molecular Formula	C22H27N3O3S
SMILES	COCCO[C@H](CC1)CC[C@@H]1NC2=CC(N(C)C3=CC=C(C=C32)C4=CN=CS4)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4182 mL	12.0910 mL	24.1820 mL
5 mM	0.4836 mL	2.4182 mL	4.8364 mL
10 mM	0.2418 mL	1.2091 mL	2.4182 mL
50 mM	0.0484 mL	0.2418 mL	0.4836 mL

Description

CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively.

Targets

mCD38 ^[1] (Cell-free assay)	hCD38 ^[1] (Cell-free assay)
1.9 nM	7.3 nM

In vitro

CD38 inhibitor 1 (compound 78c) increases NAD+ levels, resulting in activation of pro-longevity and health span-related factors including sirtuins, AMPK, and PARPs.

References

[1] Curt D Haffner, et al. J Med Chem. 2015 Apr 23;58(8):3548-71.
[2] Mariana G Tarragó, et al. Cell Metab. 2018 May 1;27(5):1081-1095.e10.