[CAS NO. 2408648-20-2] BO-264
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [2408648-20-2]
Store
Catalog
SLK-S8965
Brand
Selleck
CAS
2408648-20-2
DESCRIPTION [2408648-20-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 353.38 |
| Molecular Formula | C18H19N5O3 |
| SMILES | COC1=CC=C(C2=NOC(NC3=NC(N4CCOCC4)=NC=C3)=C2)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8298 mL | 14.1491 mL | 28.2981 mL |
| 5 mM | 0.5660 mL | 2.8298 mL | 5.6596 mL |
| 10 mM | 0.2830 mL | 1.4149 mL | 2.8298 mL |
| 50 mM | 0.0566 mL | 0.2830 mL | 0.5660 mL |
Description
BO-264 is a potent and orally active inhibitor of with IC50 of 188 nM and Kd of 1.5 nM. BO-264 specifically blocks the function of fusion protein. BO-264 induces SAC-dependent mitotic arrest, and DNA damage with antitumor activities.
In vitro
BO-264 significantly decreases centrosomal TACC3 during both mitosis and interphase. BO-264 displays potent anti-proliferative activity in the NCI- 60 cell line panel compromising nine different cancer types. BO-264 significantly inhibits the growth of cells harboring FGFR3-TACC3 fusion, an oncogenic driver in diverse malignancies.
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.