[CAS NO. 2237268-08-3] SBI-797812
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PRODUCTS SPECIFICATIONS [2237268-08-3]
Store
Catalog
SLK-S8980
Brand
Selleck
CAS
2237268-08-3
DESCRIPTION [2237268-08-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 402.47 |
| Molecular Formula | C19H22N4O4S |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4847 mL | 12.4233 mL | 24.8466 mL |
| 5 mM | 0.4969 mL | 2.4847 mL | 4.9693 mL |
| 10 mM | 0.2485 mL | 1.2423 mL | 2.4847 mL |
| 50 mM | 0.0497 mL | 0.2485 mL | 0.4969 mL |
Description
SBI-797812 is a activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to . SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.
Targets
| NAMPT [1] |
In vitro
SBI-797812 shifts the NAMPT reaction equilibrium towards NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. Treatment of cultured cells with SBI-797812 increases intracellular NMN and NAD+.
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